Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies.

Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies.

The recently reported "UK variant" (B.1.1.7) of SARS-CoV-2 is thought to be more infectious than previously circulating strains as a result of several changes, including the N501Y mutation. We present a 2.9-Å resolution cryo-electron microscopy (cryo-EM) structure of the complex between th...

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Bibliographic Details
Main Authors: Xing Zhu, Dhiraj Mannar, Shanti S Srivastava, Alison M Berezuk, Jean-Philippe Demers, James W Saville, Karoline Leopold, Wei Li, Dimiter S Dimitrov, Katharine S Tuttle, Steven Zhou, Sagar Chittori, Sriram Subramaniam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001237

Internet

https://doi.org/10.1371/journal.pbio.3001237

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