Metformin Suppresses the Progress of Diabetes-Accelerated Atherosclerosis by Inhibition of Vascular Smooth Muscle Cell Migration Through AMPK–Pdlim5 Pathway

Metformin Suppresses the Progress of Diabetes-Accelerated Atherosclerosis by Inhibition of Vascular Smooth Muscle Cell Migration Through AMPK–Pdlim5 Pathway

Backgrounds: Our previous work revealed that AMP-activated protein kinase (AMPK) activation inhibits vascular smooth muscle cell migration in vitro by phosphorylating PDZ and LIM domain 5 (Pdlim5). As metformin is an AMPK activator, we used a mouse vascular smooth muscle cell (VSMC) line and a Myh11...

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Bibliographic Details
Main Authors: Yi Yan, Ting Li, Zhonghao Li, Mingyuan He, Dejiang Wang, Yingyi Xu, Xuewen Yang, Yuanyuan Bai, Yi Lao, Zhiyong Zhang, Wei Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
metformin
Pdlim5
AMPK
diabetes
vascular smooth cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.690627/full

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