Prodigiosin-Emerged PI3K/Beclin-1-Independent Pathway Elicits Autophagic Cell Death in Doxorubicin-Sensitive and -Resistant Lung Cancer

Prodigiosin-Emerged PI3K/Beclin-1-Independent Pathway Elicits Autophagic Cell Death in Doxorubicin-Sensitive and -Resistant Lung Cancer

Prodigiosin (PG) belongs to a family of prodiginines isolated from gram-negative bacteria. It is a water insoluble red pigment and a potent proapoptotic compound. This study elucidates the anti-tumor activity and underlying mechanism of PG in doxorubicin-sensitive (Dox-S) and doxorubicin-resistant (...

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Bibliographic Details
Main Authors: Wei-Jun Chiu, Shian-Ren Lin, Yu-Hsin Chen, May-Jwan Tsai, Max K. Leong, Ching-Feng Weng
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Journal of Clinical Medicine
Subjects:
prodigiosin
doxorubicin resistant
lung cancer
intratracheal inoculation
Online Access:http://www.mdpi.com/2077-0383/7/10/321

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