Suppression of Netrin-1 attenuates angiotension II-induced cardiac remodeling through the PKC/MAPK signaling pathway

Suppression of Netrin-1 attenuates angiotension II-induced cardiac remodeling through the PKC/MAPK signaling pathway

Background: Myocardial remodeling caused by angiotensin II (Ang II) is essential for the pathological process of heart failure. Netrin-1, which is an axonal guidance cue, has been shown to be involved in the inflammatory response, tumorigenesis, and angiogenesis in non-neuronal tissues. However, the...

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Bibliographic Details
Main Authors: Gaojun Wu, Zhengxian Wang, Peiren Shan, Shanjun Huang, Shuang Lin, Weijian Huang, Zhouqing Huang
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Netrin-1
Cardiac remodeling
AT1R/ PKCα/MAPK
Angiotensin II
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220306880

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