Wnt Signaling in Ovarian Cancer Stemness, EMT, and Therapy Resistance

Wnt Signaling in Ovarian Cancer Stemness, EMT, and Therapy Resistance

Ovarian cancers represent the deadliest among gynecologic malignancies and are characterized by a hierarchical structure with cancer stem cells (CSCs) endowed with self-renewal and the capacity to differentiate. The Wnt/β-catenin signaling pathway, known to regulate stemness in a broad spec...

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Bibliographic Details
Main Authors: Miriam Teeuwssen, Riccardo Fodde
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Journal of Clinical Medicine
Subjects:
ovarian cancer
wnt signaling
cancer stem cells
tumor progression
therapy resistance
exosomes
Online Access:https://www.mdpi.com/2077-0383/8/10/1658

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