Cellular Technologies in Traumatology: from Cells to Tissue Engineering

Severe injuries of the musculoskeletal system with damage of bone and cartilaginous tissue are associated with the necessity to find ways for replacement of defects. Current methods of treatment including the usage of autografts and modern synthetic materials are often not effective enough. The arti...

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Main Authors: N. N. Dremina, I. S. Trukhan, I. A. Shurygina
Format: Article
Language:Russian
Published: Scientific Сentre for Family Health and Human Reproduction Problems 2021-01-01
Series:Acta Biomedica Scientifica
Subjects:
Online Access:https://www.actabiomedica.ru/jour/article/view/2497
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spelling doaj-3c08a09a095a490ca0a3f9a7920aad232021-08-17T13:53:06ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962021-01-0156667610.29413/ABS.2020-5.6.82076Cellular Technologies in Traumatology: from Cells to Tissue EngineeringN. N. Dremina0I. S. Trukhan1I. A. Shurygina2Irkutsk Scientific Centre of Surgery and TraumatologyIrkutsk Scientific Centre of Surgery and TraumatologyIrkutsk Scientific Centre of Surgery and TraumatologySevere injuries of the musculoskeletal system with damage of bone and cartilaginous tissue are associated with the necessity to find ways for replacement of defects. Current methods of treatment including the usage of autografts and modern synthetic materials are often not effective enough. The article deals with the prospects for developing the new areas in the traumatological pathology treatment based on the cell technologies application. Both medical and ethical aspects of the cell technology usage and the utilizing various sources of cell material for transplantation are discussed in detail. Special attention is devoted to application of the mesenchymal stem cells as  the most suitable material for bone and cartilage repair. These cells possess the properties of multipotent stem cells that can adhere to plastic surfaces, differentiate into various cells, including chondroblasts, osteoblasts, and migrate to the damaged area. It is shown that the number and biological characteristics of the isolated cells depend on the tissue, the cell isolation method, and the culture medium. During the cultivation of mesenchymal  stem cells, the true marker of which is Stro-1, it is necessary to monitor the duration and number of passages, because these values are inversely correlated with the differentiating potential of cells, and spontaneous transformation according to oncogenic pathway may occur. Thus, mesenchymal stem cells represent a current material for the reconstruction of hard tissues. Despite ethical and technological problems, cell technologies are a promising approach in regenerative medicine.https://www.actabiomedica.ru/jour/article/view/2497сell technologiesmesenchymal stem cellsreparationtraumatologybonecartilage
collection DOAJ
language Russian
format Article
sources DOAJ
author N. N. Dremina
I. S. Trukhan
I. A. Shurygina
spellingShingle N. N. Dremina
I. S. Trukhan
I. A. Shurygina
Cellular Technologies in Traumatology: from Cells to Tissue Engineering
Acta Biomedica Scientifica
сell technologies
mesenchymal stem cells
reparation
traumatology
bone
cartilage
author_facet N. N. Dremina
I. S. Trukhan
I. A. Shurygina
author_sort N. N. Dremina
title Cellular Technologies in Traumatology: from Cells to Tissue Engineering
title_short Cellular Technologies in Traumatology: from Cells to Tissue Engineering
title_full Cellular Technologies in Traumatology: from Cells to Tissue Engineering
title_fullStr Cellular Technologies in Traumatology: from Cells to Tissue Engineering
title_full_unstemmed Cellular Technologies in Traumatology: from Cells to Tissue Engineering
title_sort cellular technologies in traumatology: from cells to tissue engineering
publisher Scientific Сentre for Family Health and Human Reproduction Problems
series Acta Biomedica Scientifica
issn 2541-9420
2587-9596
publishDate 2021-01-01
description Severe injuries of the musculoskeletal system with damage of bone and cartilaginous tissue are associated with the necessity to find ways for replacement of defects. Current methods of treatment including the usage of autografts and modern synthetic materials are often not effective enough. The article deals with the prospects for developing the new areas in the traumatological pathology treatment based on the cell technologies application. Both medical and ethical aspects of the cell technology usage and the utilizing various sources of cell material for transplantation are discussed in detail. Special attention is devoted to application of the mesenchymal stem cells as  the most suitable material for bone and cartilage repair. These cells possess the properties of multipotent stem cells that can adhere to plastic surfaces, differentiate into various cells, including chondroblasts, osteoblasts, and migrate to the damaged area. It is shown that the number and biological characteristics of the isolated cells depend on the tissue, the cell isolation method, and the culture medium. During the cultivation of mesenchymal  stem cells, the true marker of which is Stro-1, it is necessary to monitor the duration and number of passages, because these values are inversely correlated with the differentiating potential of cells, and spontaneous transformation according to oncogenic pathway may occur. Thus, mesenchymal stem cells represent a current material for the reconstruction of hard tissues. Despite ethical and technological problems, cell technologies are a promising approach in regenerative medicine.
topic сell technologies
mesenchymal stem cells
reparation
traumatology
bone
cartilage
url https://www.actabiomedica.ru/jour/article/view/2497
work_keys_str_mv AT nndremina cellulartechnologiesintraumatologyfromcellstotissueengineering
AT istrukhan cellulartechnologiesintraumatologyfromcellstotissueengineering
AT iashurygina cellulartechnologiesintraumatologyfromcellstotissueengineering
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