Alcohol and the clinical picture of gout

• Main Authors: V G Barskova, M S Eliseev, V A Nasonova, E L Nasonov, M S Yeliseyev, Ye L Nasonov
• Format: Article
• Language: Russian
• Published: IMA-PRESS LLC 2007-09-01
• Series: Современная ревматология
• Online Access: https://mrj.ima-press.net/mrj/article/view/122

Tsel' issledovaniya. Izuchenie vliyaniya alkogolya na klinicheskie proyavleniya u bol'nykh podagricheskim artritom. Material i metody. V issledovanie vklyucheny 280 muzhchin, bol'nykh podagroy (kriterii S.L. Wallace). Dlya vyyavleniya skrytoy tyagi k alkogolyu ispol'zovalsya voprosnik CAGE, putem oprosa vyyavlyalos' kolichestvo prinimaemogo alkogolya v nedelyu. U vsekh bol'nykh otsenivali antropometricheskie pokazateli, syvorotochnye urovni pechenochnykh fermentov, bilirubina, kreatinina, mochevoy kisloty, mocheviny, lipidnogo obmena, klinicheskiy analiz krovi, kontsentratsiyu SRB. Rasschityvali 10-letniy total'nyy risk (v %) razvitiya koronarnykh bolezney serdtsa, infarkta miokarda i kardiovaskulyarnoy smerti. Rezul'taty issledovaniya. Otmechena obratnaya svyaz' mezhdu kolichestvom upotreblyaemogo alkogolya i vozrastom nachala bolezni (r=-0,19, p<0,001), a takzhe vozrastom bol'nogo (r=-0,19, p<0,001), mezhdu u -GTP i indeksom massy tela (r=0,11, p<0,05), syvorotochnym urovnem mochevoy kisloty (r=0,12, p<0,03), SOE (r=0,16, p<0,01) i SRB (r=0,16, p<0,01). U CAGE- pozitivnykh bol'nykh na moment osmotra dostoverno chashche otmechalis' vospalenie sustavov (p<0,05) i khronicheskiy artrit (p<0,01). Zaklyuchenie. Vyyavlena zavisimost' mezhdu vozrastom debyuta podagry i kolichestvom prinimaemogo alkogolya. Uchityvaya, chto molodye bol'nye prinimali bol'shee kolichestvo alkogolya, pryamoy svyazi mezhdu priemom alkogolya i kardiovaskulyarnym riskom ne otmechalos'. Odnako svyaz' mezhdu priemom alkogolya i vyrazhennost'yu vistseral'nogo ozhireniya, podagricheskogo vospaleniya, urovnem mochevoy kisloty mozhet govorit' o kosvennom povyshenii u nikh kardiovaskulyarnogo riska.