The SUMO-Conjugase Ubc9 Prevents the Degradation of the Dopamine Transporter, Enhancing Its Cell Surface Level and Dopamine Uptake

The SUMO-Conjugase Ubc9 Prevents the Degradation of the Dopamine Transporter, Enhancing Its Cell Surface Level and Dopamine Uptake

The dopamine transporter (DAT) is a plasma membrane protein responsible for the uptake of released dopamine back to the presynaptic terminal and ending dopamine neurotransmission. The DAT is the molecular target for cocaine and amphetamine as well as a number of pathological conditions including aut...

Full description

Bibliographic Details
Main Authors: Etienne Cartier, Jennie Garcia-Olivares, Eric Janezic, Juan Viana, Michael Moore, Min Landon Lin, Jeffrey L. Caplan, Gonzalo Torres, Yong-Hwan Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
dopamine transporter
SUMOylation
Ubc9
ubiquitin
lysosome
proteostasis
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00035/full

Similar Items

Similar Items