The Phosphodiesterase Type 5 Inhibitor Sildenafil Improves DNA Stability and Redox Homeostasis in Systemic Sclerosis Fibroblasts Exposed to Reactive Oxygen Species

The Phosphodiesterase Type 5 Inhibitor Sildenafil Improves DNA Stability and Redox Homeostasis in Systemic Sclerosis Fibroblasts Exposed to Reactive Oxygen Species

Systemic sclerosis (SSc) is a multi-system connective tissue disease characterized by the increased deposition of extracellular matrix proteins such as collagen and fibronectin. Although the pathogenesis is not completely understood, a number of studies suggest that free radicals could be the major...

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Bibliographic Details
Main Authors: Luigi Di Di Luigi, Guglielmo Duranti, Ambra Antonioni, Paolo Sgrò, Roberta Ceci, Clara Crescioli, Stefania Sabatini, Andrea Lenzi, Daniela Caporossi, Francesco Del Del Galdo, Ivan Dimauro, Cristina Antinozzi
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Antioxidants
Subjects:
oxidative stress
sildenafil
DNA damage
systemic sclerosis
Online Access:https://www.mdpi.com/2076-3921/9/9/786

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