The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni

The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni

The CsrA protein binds to and represses translation of certain bacterial mRNAs. Here, Dugar et al. show for the human pathogen Campylobacter jejunithat the major flagellin mRNA acts as both a target and a regulatory 'sponge' for CsrA, and is localized at the cell poles in a translation-dep...

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Main Authors: Gaurav Dugar, Sarah L. Svensson, Thorsten Bischler, Sina Wäldchen, Richard Reinhardt, Markus Sauer, Cynthia M. Sharma
Format: Article
Language:English
Published: Nature Publishing Group 2016-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11667
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spelling doaj-3be9406422e4440bb0325020fd9d1cf92021-05-11T10:40:15ZengNature Publishing GroupNature Communications2041-17232016-05-017111810.1038/ncomms11667The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuniGaurav Dugar0Sarah L. Svensson1Thorsten Bischler2Sina Wäldchen3Richard Reinhardt4Markus Sauer5Cynthia M. Sharma6Research Centre for Infectious Diseases (ZINF), University of WürzburgResearch Centre for Infectious Diseases (ZINF), University of WürzburgResearch Centre for Infectious Diseases (ZINF), University of WürzburgDepartment of Biotechnology and Biophysics, University of Würzburg, Am HublandMax Planck Genome Centre Cologne, Max Planck Institute for Plant Breeding ResearchDepartment of Biotechnology and Biophysics, University of Würzburg, Am HublandResearch Centre for Infectious Diseases (ZINF), University of WürzburgThe CsrA protein binds to and represses translation of certain bacterial mRNAs. Here, Dugar et al. show for the human pathogen Campylobacter jejunithat the major flagellin mRNA acts as both a target and a regulatory 'sponge' for CsrA, and is localized at the cell poles in a translation-dependent manner.https://doi.org/10.1038/ncomms11667
collection DOAJ
language English
format Article
sources DOAJ
author Gaurav Dugar
Sarah L. Svensson
Thorsten Bischler
Sina Wäldchen
Richard Reinhardt
Markus Sauer
Cynthia M. Sharma
spellingShingle Gaurav Dugar
Sarah L. Svensson
Thorsten Bischler
Sina Wäldchen
Richard Reinhardt
Markus Sauer
Cynthia M. Sharma
The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni
Nature Communications
author_facet Gaurav Dugar
Sarah L. Svensson
Thorsten Bischler
Sina Wäldchen
Richard Reinhardt
Markus Sauer
Cynthia M. Sharma
author_sort Gaurav Dugar
title The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni
title_short The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni
title_full The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni
title_fullStr The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni
title_full_unstemmed The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni
title_sort csra-fliw network controls polar localization of the dual-function flagellin mrna in campylobacter jejuni
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-05-01
description The CsrA protein binds to and represses translation of certain bacterial mRNAs. Here, Dugar et al. show for the human pathogen Campylobacter jejunithat the major flagellin mRNA acts as both a target and a regulatory 'sponge' for CsrA, and is localized at the cell poles in a translation-dependent manner.
url https://doi.org/10.1038/ncomms11667
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