Simultaneous estimation of silodosin and silodosin β-D-glucuronide in human plasma using LC-MS/MS for a pharmacokinetic study

Simultaneous estimation of silodosin and silodosin β-D-glucuronide in human plasma using LC-MS/MS for a pharmacokinetic study

A rapid, simple, sensitive and selective LC-MS/MS method has been developed and validated for simultaneous quantification of silodosin and silodosin β-D-glucuronide human plasma using stable labelled isotopes as internal standards. Solid phase extraction technique (SPE) was used for the extraction a...

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Bibliographic Details
Main Authors: Siva Sankara Rao Yadlapalli, Naresh Kumar Katari, Surendra Babu Manabolu, Vasu Babu Ravi
Format: Article
Language:English
Published: Taylor & Francis Group 2018-07-01
Series:Journal of Taibah University for Science
Subjects:
Silodosin
silodosin β-D-glucuronide
human plasma
LC–MS/MS
method development
pharmacokinetics
quantification
Online Access:http://dx.doi.org/10.1080/16583655.2018.1490562

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