A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein

Baicalein (BE) is one of the main active flavonoids representing the variety of pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate and poor oral absorption limit the therapeutic applications. I...

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Bibliographic Details
Main Authors: Jiaxin Pi, Shuya Wang, Wen Li, Dereje Kebebe, Ying Zhang, Bing Zhang, Dongli Qi, Pan Guo, Nan Li, Zhidong Liu
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Asian Journal of Pharmaceutical Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087617309492