Detachment and recovery index: A new parameter measuring powder compressibility

• Main Author: SAS Aly
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2010-01-01
• Series: Journal of Advanced Pharmaceutical Technology & Research
• Subjects: Compression; Density; DRI
• Online Access: http://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=4;spage=406;epage=414;aulast=Aly

This investigation introduces a simple and reliable approach to measure the compressibility of some direct compression excipients in tablet systems made from compressible components. The claim made here is that: the total reduction, ΔL T , in the thickness of a tablet batch due to compression at a confined machine settings is the integral sum of small reductions generated by the compressible components in the batch. The reduction value, ΔL E , generated by a single or a blend of excipients in a batch could be calculated and was found to correlate to its concentration, C, by the relation: ΔL E =A E.C x. The constants AE and x concern the reduction tendency, RT, of the excipient particles due to compression, and detachment and recovery index (DRI), respectively. Some physicomechanical parameters characterizing the compression behavior of an excipient in a tablet batch could be determined and were found to be functions of the determine DRI of the excipient in the batch.