Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure

Heart failure has a heterogeneous etiology and the genetic underpinnings are not well understood. Here, Arvanitis et al. perform GWAS meta-analysis including 10,976 heart failure cases and 437,573 controls, identify new loci near ABO and ACTN2 and show that deletion of a ACTN2 enhancer leads to redu...

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Main Authors:	Marios Arvanitis, Emmanouil Tampakakis, Yanxiao Zhang, Wei Wang, Adam Auton, 23andMe Research Team, Diptavo Dutta, Stephanie Glavaris, Ali Keramati, Nilanjan Chatterjee, Neil C. Chi, Bing Ren, Wendy S. Post, Alexis Battle
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-14843-7

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spelling	doaj-3bc2253203ec49828e938618eb6f185d2021-05-11T08:46:50ZengNature Publishing GroupNature Communications2041-17232020-02-0111111210.1038/s41467-020-14843-7Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failureMarios Arvanitis0Emmanouil Tampakakis1Yanxiao Zhang2Wei Wang3Adam Auton423andMe Research TeamDiptavo Dutta5Stephanie Glavaris6Ali Keramati7Nilanjan Chatterjee8Neil C. Chi9Bing Ren10Wendy S. Post11Alexis Battle12Department of Biomedical Engineering, Johns Hopkins UniversityDepartment of Medicine, Division of Cardiology, Johns Hopkins UniversityLudwig Institute for Cancer Research23andMe, Inc.23andMe, Inc.Department of Biomedical Engineering, Johns Hopkins UniversityDepartment of Medicine, Division of Cardiology, Johns Hopkins UniversityDepartment of Medicine, Division of Cardiology, Johns Hopkins UniversityDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public HealthDepartment of Medicine, Division of Cardiology, University of California, San DiegoLudwig Institute for Cancer ResearchDepartment of Medicine, Division of Cardiology, Johns Hopkins UniversityDepartment of Biomedical Engineering, Johns Hopkins UniversityHeart failure has a heterogeneous etiology and the genetic underpinnings are not well understood. Here, Arvanitis et al. perform GWAS meta-analysis including 10,976 heart failure cases and 437,573 controls, identify new loci near ABO and ACTN2 and show that deletion of a ACTN2 enhancer leads to reduced ACTN2 expression in differentiating cardiomyocytes.https://doi.org/10.1038/s41467-020-14843-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Marios Arvanitis Emmanouil Tampakakis Yanxiao Zhang Wei Wang Adam Auton 23andMe Research Team Diptavo Dutta Stephanie Glavaris Ali Keramati Nilanjan Chatterjee Neil C. Chi Bing Ren Wendy S. Post Alexis Battle
spellingShingle	Marios Arvanitis Emmanouil Tampakakis Yanxiao Zhang Wei Wang Adam Auton 23andMe Research Team Diptavo Dutta Stephanie Glavaris Ali Keramati Nilanjan Chatterjee Neil C. Chi Bing Ren Wendy S. Post Alexis Battle Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure Nature Communications
author_facet	Marios Arvanitis Emmanouil Tampakakis Yanxiao Zhang Wei Wang Adam Auton 23andMe Research Team Diptavo Dutta Stephanie Glavaris Ali Keramati Nilanjan Chatterjee Neil C. Chi Bing Ren Wendy S. Post Alexis Battle
author_sort	Marios Arvanitis
title	Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
title_short	Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
title_full	Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
title_fullStr	Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
title_full_unstemmed	Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
title_sort	genome-wide association and multi-omic analyses reveal actn2 as a gene linked to heart failure
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-02-01
description	Heart failure has a heterogeneous etiology and the genetic underpinnings are not well understood. Here, Arvanitis et al. perform GWAS meta-analysis including 10,976 heart failure cases and 437,573 controls, identify new loci near ABO and ACTN2 and show that deletion of a ACTN2 enhancer leads to reduced ACTN2 expression in differentiating cardiomyocytes.
url	https://doi.org/10.1038/s41467-020-14843-7
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Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure

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