The Pleiotropic Immunomodulatory Functions of IL-33 and Its Implications in Tumor Immunity

The Pleiotropic Immunomodulatory Functions of IL-33 and Its Implications in Tumor Immunity

Interleukin-33 (IL-33) is a IL-1 family member of cytokines exerting pleiotropic activities. In the steady-state, IL-33 is expressed in the nucleus of epithelial, endothelial, and fibroblast-like cells acting as a nuclear protein. In response to tissue damage, infections or necrosis IL-33 is release...

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Bibliographic Details
Main Authors: Claudia Afferni, Carla Buccione, Sara Andreone, Maria Rosaria Galdiero, Gilda Varricchi, Gianni Marone, Fabrizio Mattei, Giovanna Schiavoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
IL-33
cancer
immune cell subsets
tumor immunology
IL-33 isoforms
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02601/full

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