The structure of cerebrosides in Gaucher's disease*
Crystalline cerebrosides were isolated from the spleen of a woman with Gaucher's disease. The cerebrosides accounted for 38 per cent of the total spleen lipids and 0.89 per cent of the fresh spleen. The sugar moiety of the cerebrosides was found to be glucose and its position of attachment was...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1960-04-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520390635 |
| Summary: | Crystalline cerebrosides were isolated from the spleen of a woman with Gaucher's disease. The cerebrosides accounted for 38 per cent of the total spleen lipids and 0.89 per cent of the fresh spleen. The sugar moiety of the cerebrosides was found to be glucose and its position of attachment was establihed to be on the primary hydroxyl group of sphingosine. The double bond in the sphingosine moiety had the trans configuration. The fatty acids of the cerebroside were determined by gas chromatography and paper chromatography and found to be mainly lignoceric, behenic, and palmitic acid. Small amounts of arachidic and stearic acids were also present. |
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| ISSN: | 0022-2275 |