Dendritic cells from Crohn's disease patients show aberrant STAT1 and STAT3 signaling.

Dendritic cells from Crohn's disease patients show aberrant STAT1 and STAT3 signaling.

Abnormalities of dendritic cells (DCs) and STAT proteins have been reported in Crohn's disease (CD). Studies on JAK/STAT signaling in DCs are, however, lacking in CD. We applied a flowcytometric single-cell-based phosphoepitope assay to evaluate STAT1 and STAT3 pathways in DC subsets from CD pa...

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Bibliographic Details
Main Authors: Janne K Nieminen, Mirja Niemi, Taina Sipponen, Harri M Salo, Paula Klemetti, Martti Färkkilä, Jukka Vakkila, Outi Vaarala
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23950992/pdf/?tool=EBI

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