Up-Regulation of Glioma-Associated Oncogene Homolog 1 Expression by Serum Starvation Promotes Cell Survival in ER-Positive Breast Cancer Cells

Up-Regulation of Glioma-Associated Oncogene Homolog 1 Expression by Serum Starvation Promotes Cell Survival in ER-Positive Breast Cancer Cells

Background/Aims: Cancer cells are resistant to ischemia and starvation. Glioma-associated oncogene homolog 1 (Gli1) is a positive transcriptional activator of Hedgehog (Hh) pathway and plays an essential role in the development of cancers, including breast cancer. However, how Gli1 promotes cell sur...

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Bibliographic Details
Main Authors: Juan Xu, Gaoxiang Huang, Zongjing Zhang, Jieying Zhao, Mingzhuo Zhang, Yan Wang, Zhimin Liu, Jian Lu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Gli1
Breast cancer
Cell survival
cIAP2
NF-κB
Online Access:http://www.karger.com/Article/FullText/430156

Internet

http://www.karger.com/Article/FullText/430156

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