Growth condition dependency is the major cause of non-responsiveness upon genetic perturbation.

Investigating the role and interplay between individual proteins in biological processes is often performed by assessing the functional consequences of gene inactivation or removal. Depending on the sensitivity of the assay used for determining phenotype, between 66% (growth) and 53% (gene expressio...

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Bibliographic Details
Main Authors: Saman Amini, Frank C P Holstege, Patrick Kemmeren
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5336285?pdf=render