Rhythmic potassium transport regulates the circadian clock in human red blood cells

Circadian rhythms usually rely on cyclic variations in gene expression. Red blood cells, however, display circadian rhythms while being devoid of nuclear DNA. Here, Henslee and colleagues show that circadian rhythms in isolated human red blood cells are dependent on rhythmic transport of K+ ions.

Bibliographic Details
Main Authors:	Erin A. Henslee, Priya Crosby, Stephen J. Kitcatt, Jack S. W. Parry, Andrea Bernardini, Rula G. Abdallat, Gabriella Braun, Henry O. Fatoyinbo, Esther J. Harrison, Rachel S. Edgar, Kai F. Hoettges, Akhilesh B. Reddy, Rita I. Jabr, Malcolm von Schantz, John S. O’Neill, Fatima H. Labeed
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02161-4

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spelling	doaj-3b9cc98ebe9f4f4a828664161f701abc2021-05-11T07:44:06ZengNature Publishing GroupNature Communications2041-17232017-12-018111010.1038/s41467-017-02161-4Rhythmic potassium transport regulates the circadian clock in human red blood cellsErin A. Henslee0Priya Crosby1Stephen J. Kitcatt2Jack S. W. Parry3Andrea Bernardini4Rula G. Abdallat5Gabriella Braun6Henry O. Fatoyinbo7Esther J. Harrison8Rachel S. Edgar9Kai F. Hoettges10Akhilesh B. Reddy11Rita I. Jabr12Malcolm von Schantz13John S. O’Neill14Fatima H. Labeed15Department of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of SurreyMRC Laboratory of Molecular BiologyDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of SurreyDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of SurreyDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of SurreyDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of SurreyDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of SurreyDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of SurreyDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of SurreyMRC Laboratory of Molecular BiologyDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of SurreyThe Francis Crick InstituteFaculty of Health and Medical Sciences, University of SurreyFaculty of Health and Medical Sciences, University of SurreyMRC Laboratory of Molecular BiologyDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of SurreyCircadian rhythms usually rely on cyclic variations in gene expression. Red blood cells, however, display circadian rhythms while being devoid of nuclear DNA. Here, Henslee and colleagues show that circadian rhythms in isolated human red blood cells are dependent on rhythmic transport of K+ ions.https://doi.org/10.1038/s41467-017-02161-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Erin A. Henslee Priya Crosby Stephen J. Kitcatt Jack S. W. Parry Andrea Bernardini Rula G. Abdallat Gabriella Braun Henry O. Fatoyinbo Esther J. Harrison Rachel S. Edgar Kai F. Hoettges Akhilesh B. Reddy Rita I. Jabr Malcolm von Schantz John S. O’Neill Fatima H. Labeed
spellingShingle	Erin A. Henslee Priya Crosby Stephen J. Kitcatt Jack S. W. Parry Andrea Bernardini Rula G. Abdallat Gabriella Braun Henry O. Fatoyinbo Esther J. Harrison Rachel S. Edgar Kai F. Hoettges Akhilesh B. Reddy Rita I. Jabr Malcolm von Schantz John S. O’Neill Fatima H. Labeed Rhythmic potassium transport regulates the circadian clock in human red blood cells Nature Communications
author_facet	Erin A. Henslee Priya Crosby Stephen J. Kitcatt Jack S. W. Parry Andrea Bernardini Rula G. Abdallat Gabriella Braun Henry O. Fatoyinbo Esther J. Harrison Rachel S. Edgar Kai F. Hoettges Akhilesh B. Reddy Rita I. Jabr Malcolm von Schantz John S. O’Neill Fatima H. Labeed
author_sort	Erin A. Henslee
title	Rhythmic potassium transport regulates the circadian clock in human red blood cells
title_short	Rhythmic potassium transport regulates the circadian clock in human red blood cells
title_full	Rhythmic potassium transport regulates the circadian clock in human red blood cells
title_fullStr	Rhythmic potassium transport regulates the circadian clock in human red blood cells
title_full_unstemmed	Rhythmic potassium transport regulates the circadian clock in human red blood cells
title_sort	rhythmic potassium transport regulates the circadian clock in human red blood cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-12-01
description	Circadian rhythms usually rely on cyclic variations in gene expression. Red blood cells, however, display circadian rhythms while being devoid of nuclear DNA. Here, Henslee and colleagues show that circadian rhythms in isolated human red blood cells are dependent on rhythmic transport of K+ ions.
url	https://doi.org/10.1038/s41467-017-02161-4
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Rhythmic potassium transport regulates the circadian clock in human red blood cells

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