Co-aggregation of pro-inflammatory S100A9 with α-synuclein in Parkinson’s disease: ex vivo and in vitro studies

Co-aggregation of pro-inflammatory S100A9 with α-synuclein in Parkinson’s disease: ex vivo and in vitro studies

Abstract Background Chronic neuroinflammation is a hallmark of Parkinson’s disease (PD) pathophysiology, associated with increased levels of pro-inflammatory factors in PD brain tissues. The pro-inflammatory mediator and highly amyloidogenic protein S100A9 is involved in the amyloid-neuroinflammator...

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Main Authors: Istvan Horvath, Igor A. Iashchishyn, Roman A. Moskalenko, Chao Wang, Sebastian K. T. S. Wärmländer, Cecilia Wallin, Astrid Gräslund, Gabor G. Kovacs, Ludmilla A. Morozova-Roche
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Journal of Neuroinflammation
Subjects:
S100A9
α-Synuclein
Parkinson’s disease
Neuroinflammation
Amyloid
Cytotoxicity
Online Access:http://link.springer.com/article/10.1186/s12974-018-1210-9

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