Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy

Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy

Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert nontoxic prodrugs to cytotoxic drugs. A zone of cell kill around gene-modified cells due to transfer of toxic metabolites, known as the bysta...

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Bibliographic Details
Main Authors: Adam V. Patterson, Dean C. Singleton, Sophie Syddall, Michelle A. Hunt, Gabi U. Dachs
Format: Article
Language:English
Published: MDPI AG 2009-11-01
Series:Molecules
Subjects:
nitroreductase
thymidine kinase
cytosine deaminase
alkylating agents
chemotherapy
Online Access:http://www.mdpi.com/1420-3049/14/11/4517/

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