Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550

• Main Authors: Johannes F. Imhoff, Gerhard Bringmann, Torsten Bruhn, Arlette Erhard, Birgit Ohlendorf, Nils Jansen
• Format: Article
• Language: English
• Published: MDPI AG 2013-03-01
• Series: Marine Drugs
• Subjects: marine natural product; azaphilone; pentaketide; Bartalinia robillardoides; Tethya aurantium
• Online Access: http://www.mdpi.com/1660-3397/11/3/800

Microbial studies of the Mediterranean sponge Tethya aurantium led to the isolation of the fungus Bartalinia robillardoides strain LF550. The strain produced a number of secondary metabolites belonging to the chloroazaphilones. This is the first report on the isolation of chloroazaphilones of a fungal strain belonging to the genus Bartalinia. Besides some known compounds (helicusin A (1) and deacetylsclerotiorin (2)), three new chloroazaphilones (helicusin E (3); isochromophilone X (4) and isochromophilone XI (5)) and one new pentaketide (bartanolide (6)) were isolated. The structure elucidations were based on spectroscopic analyses. All isolated compounds revealed different biological activity spectra against a test panel of four bacteria: three fungi; two tumor cell lines and two enzymes.