Evaluation of acute wound healing potential of red dragon fruit (Hylocereus Polyrhizus) extract cream on type III collagen and Epidermal Growth Factor (EGF) levels: An animal study

• Main Authors: Takdir Tahir, Nur Febrianti, Sri Wahyuni, Rabia, Yuliana Syam
• Format: Article
• Language: English
• Published: Elsevier España 2020-06-01
• Series: Medicina Clínica Práctica
• Subjects: Hylocereus Polyrhizus; Type III collagen; EGF; Wound healing
• Online Access: http://www.sciencedirect.com/science/article/pii/S2603924920300136

Objective: To evaluate the acute wound healing potential of RDFE cream on type III collagen and EGF levels. Method: Male Albino Wistar rats have randomly divided into three groups: negative control received base cream, positive control administered with 10% zalf povidone and RDFE group was treated with RDFE cream. The healing effects were assessed on EGF, type III collagen, wound diameter, tissue granulation, and epithelization, for 3, 7, 11, and 14 days post-treatment. Results: On the 3rd-day post-treatment, the greatest reduction in wound diameters were shown significantly in the positive control among groups (p < 0.05). Although the data were statistically insignificant, RDFE groups showed the highest level of type III collagen among groups after 7-day treatment (p > 0.05). Conclusion: The effect of RDFE cream in the wound healing process on type III collagen appeared on day 7. However, an increase of EGF levels was not observed following RDFE treatment.