UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

To adapt in an ever-changing environment, cells must integrate physical and chemical signals and translate them into biological meaningful information through complex signaling pathways. By combining lipidomic and proteomic approaches with functional analysis, we have shown that ubiquitin domain-con...

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Bibliographic Details
Main Authors: Stéphanie Torrino, Victor Tiroille, Bastien Dolfi, Maeva Dufies, Charlotte Hinault, Laurent Bonesso, Sonia Dagnino, Jennifer Uhler, Marie Irondelle, Anne-sophie Gay, Lucile Fleuriot, Delphine Debayle, Sandra Lacas-Gervais, Mireille Cormont, Thomas Bertero, Frederic Bost, Jerome Gilleron, Stephan Clavel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
EGFR
UBTD1
ubiquitination
cell proliferation
ceramide
Online Access:https://elifesciences.org/articles/68348

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