WEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage

WEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage

Genomically unstable cancers are dependent on specific cell cycle checkpoints to maintain viability and prevent apoptosis. The cell cycle checkpoint protein WEE1 is highly expressed in genomically unstable cancers, including diffuse large B-cell lymphoma (DLBCL). Although WEE1 inhibition effectively...

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Bibliographic Details
Main Authors: Mathilde Rikje Willemijn de Jong, Myra Langendonk, Bart Reitsma, Pien Herbers, Marcel Nijland, Gerwin Huls, Anke van den Berg, Emanuele Ammatuna, Lydia Visser, Tom van Meerten
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
diffuse large b-cell lymphoma
bh3 profiling
wee1
azd1775
venetoclax
navitoclax
Online Access:https://www.mdpi.com/2072-6694/11/11/1743

Internet

https://www.mdpi.com/2072-6694/11/11/1743

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