A validated mouse model capable of recapitulating the protective effects of female sex hormones on ascending aortic aneurysms and dissections (AADs)

A validated mouse model capable of recapitulating the protective effects of female sex hormones on ascending aortic aneurysms and dissections (AADs)

Abstract Fewer females develop AADs (ascending aortic aneurysms and dissections) and the reasons for this protection remain poorly understood. The present study seeks to develop a mouse model that may be utilized to address this sexual dimorphism. Adult normolipidemic mice were challenged with BAPN...

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Bibliographic Details
Main Authors: Xiaoyan Qi, Fen Wang, Changzoon Chun, Lennon Saldarriaga, Zhisheng Jiang, Eric Y. Pruitt, George J. Arnaoutakis, Gilbert R. Upchurch Jr, Zhihua Jiang
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:Physiological Reports
Subjects:
aortic dissection
inflammation
model
rupture
sex
Online Access:https://doi.org/10.14814/phy2.14631

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