Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

<p>Abstract</p> <p>Background</p> <p>In preparation for potential clinical development of Ab-01, an antagonistic antibody directed against the IL21R, studies were undertaken to address translational medicine needs that fall into four categories: 1) development of a phar...

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Bibliographic Details
Main Authors: Young Deborah, LaVallie Edward R, Allen Scott W, Smith Michael F, Bree Andrea G, Guo Yongjing, Hill Andrew A, Weaver Amy A, Jain Sadhana, Arai Maya, Bloom Laird, Adkins Karissa, O'Toole Margot
Format: Article
Language:English
Published: BMC 2010-05-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/8/1/51

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