Transcriptional response of OmpC and OmpF in Escherichia coli against differential gradient of carbapenem stress

Transcriptional response of OmpC and OmpF in Escherichia coli against differential gradient of carbapenem stress

Abstract Objective This study was designed to investigate the transcriptional response of OmpF and OmpC along with an antisense RNA, MicF under concentration gradient carbapenem exposure. Result An elevation in the expression of OmpF gene under concentration gradient imipenem stress from a particula...

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Bibliographic Details
Main Authors: Shiela Chetri, Melson Singha, Deepshikha Bhowmik, Kathakali Nath, Debadatta Dhar Chanda, Atanu Chakravarty, Amitabha Bhattacharjee
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Research Notes
Subjects:
OmpF
OmpC
micF
Carbapenem
Escherichia coli
Real time PCR
Online Access:http://link.springer.com/article/10.1186/s13104-019-4177-4
Description
Summary:Abstract Objective This study was designed to investigate the transcriptional response of OmpF and OmpC along with an antisense RNA, MicF under concentration gradient carbapenem exposure. Result An elevation in the expression of OmpF gene under concentration gradient imipenem stress from a particular concentration was observed. For OmpC gene a significant decrease in the expression was noticed under concentration gradient imipenem and meropenem stress. The study showed reduction in the expression of OmpC gene against imipenem and meropenem possibly preventing the entry of carbapenem antibiotic inside the cell indicating a possible role in carbapenem resistance.
ISSN:1756-0500

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