CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance

B cell response and antibody production are generally facilitated by CD4+ follicular helper (Tfh) cells. Here the authors identify a subset of CXCR5+PD1+CD8+ Tfh cells that is normally suppressed by STAT5 signaling, so that STAT5 deficiency in mice increases the number of these CD8+ Tfh cells and in...

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Main Authors:	Yuhong Chen, Mei Yu, Yongwei Zheng, Guoping Fu, Gang Xin, Wen Zhu, Lan Luo, Robert Burns, Quan-Zhen Li, Alexander L. Dent, Nan Zhu, Weiguo Cui, Laurent Malherbe, Renren Wen, Demin Wang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-12446-5

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spelling	doaj-3b58b83ee76b4ab8925812d2906396922021-05-11T12:41:13ZengNature Publishing GroupNature Communications2041-17232019-09-0110111510.1038/s41467-019-12446-5CXCR5+PD-1+ follicular helper CD8 T cells control B cell toleranceYuhong Chen0Mei Yu1Yongwei Zheng2Guoping Fu3Gang Xin4Wen Zhu5Lan Luo6Robert Burns7Quan-Zhen Li8Alexander L. Dent9Nan Zhu10Weiguo Cui11Laurent Malherbe12Renren Wen13Demin Wang14Blood Research Institute, VersitiBlood Research Institute, VersitiBlood Research Institute, VersitiBlood Research Institute, VersitiBlood Research Institute, VersitiBlood Research Institute, VersitiBlood Research Institute, VersitiBlood Research Institute, VersitiDepartment of Immunology and Internal Medicine, University of Texas Southwestern Medical CenterDepartment of Microbiology and Immunology, Indiana University School of MedicineBlood Research Institute, VersitiBlood Research Institute, VersitiToxicology Division, Eli LillyBlood Research Institute, VersitiBlood Research Institute, VersitiB cell response and antibody production are generally facilitated by CD4+ follicular helper (Tfh) cells. Here the authors identify a subset of CXCR5+PD1+CD8+ Tfh cells that is normally suppressed by STAT5 signaling, so that STAT5 deficiency in mice increases the number of these CD8+ Tfh cells and induces concomitant production of autoantibodies.https://doi.org/10.1038/s41467-019-12446-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yuhong Chen Mei Yu Yongwei Zheng Guoping Fu Gang Xin Wen Zhu Lan Luo Robert Burns Quan-Zhen Li Alexander L. Dent Nan Zhu Weiguo Cui Laurent Malherbe Renren Wen Demin Wang
spellingShingle	Yuhong Chen Mei Yu Yongwei Zheng Guoping Fu Gang Xin Wen Zhu Lan Luo Robert Burns Quan-Zhen Li Alexander L. Dent Nan Zhu Weiguo Cui Laurent Malherbe Renren Wen Demin Wang CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance Nature Communications
author_facet	Yuhong Chen Mei Yu Yongwei Zheng Guoping Fu Gang Xin Wen Zhu Lan Luo Robert Burns Quan-Zhen Li Alexander L. Dent Nan Zhu Weiguo Cui Laurent Malherbe Renren Wen Demin Wang
author_sort	Yuhong Chen
title	CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance
title_short	CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance
title_full	CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance
title_fullStr	CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance
title_full_unstemmed	CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance
title_sort	cxcr5+pd-1+ follicular helper cd8 t cells control b cell tolerance
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-09-01
description	B cell response and antibody production are generally facilitated by CD4+ follicular helper (Tfh) cells. Here the authors identify a subset of CXCR5+PD1+CD8+ Tfh cells that is normally suppressed by STAT5 signaling, so that STAT5 deficiency in mice increases the number of these CD8+ Tfh cells and induces concomitant production of autoantibodies.
url	https://doi.org/10.1038/s41467-019-12446-5
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CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance

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