CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance
B cell response and antibody production are generally facilitated by CD4+ follicular helper (Tfh) cells. Here the authors identify a subset of CXCR5+PD1+CD8+ Tfh cells that is normally suppressed by STAT5 signaling, so that STAT5 deficiency in mice increases the number of these CD8+ Tfh cells and in...
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Bibliographic Details
| Main Authors: |
Yuhong Chen,
Mei Yu,
Yongwei Zheng,
Guoping Fu,
Gang Xin,
Wen Zhu,
Lan Luo,
Robert Burns,
Quan-Zhen Li,
Alexander L. Dent,
Nan Zhu,
Weiguo Cui,
Laurent Malherbe,
Renren Wen,
Demin Wang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-12446-5
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