Chitosan coated molybdenum sulphide nanosheet incorporated with tantalum oxide nanomaterials for improving cancer photothermal therapy

In recent years, two-dimensional nanomaterials (2D) prominent for site specific photothermal treatment (PTT), which are one of the most interesting strategy due to their maximizing cancer cell killing efficiency without the normal cells. Several robust methods are established for 2D material synthes...

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Main Authors: Srinivasan Rajasekar, Esther Monisha Martin, Santhi Kuppusamy, Cittrarasu Vetrivel
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Arabian Journal of Chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535219301388
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spelling doaj-3b29479200e54aeabd20f22b46cafd872020-11-25T01:12:29ZengElsevierArabian Journal of Chemistry1878-53522020-03-0113347414750Chitosan coated molybdenum sulphide nanosheet incorporated with tantalum oxide nanomaterials for improving cancer photothermal therapySrinivasan Rajasekar0Esther Monisha Martin1Santhi Kuppusamy2Cittrarasu Vetrivel3Kathir Institute of Health Science Wisdom Tree, Neelambur, Coimbatore 641062, Tamil Nadu, India; Corresponding author.Kathir Institute of Health Science Wisdom Tree, Neelambur, Coimbatore 641062, Tamil Nadu, IndiaDepartment of Botany, Selvam Arts and Science College, Namakkal, Tamil Nadu 637003, IndiaEthnopharmacology and Algal Biotechnology Division, Department of Botany, School of Life Science, Periyar University, Salem 636011, Tamil Nadu, IndiaIn recent years, two-dimensional nanomaterials (2D) prominent for site specific photothermal treatment (PTT), which are one of the most interesting strategy due to their maximizing cancer cell killing efficiency without the normal cells. Several robust methods are established for 2D material synthesis and improving the photothermal conversion efficiency (PCE), biocompatibility, and photostability in cancer PTT. Such preferred mechanism like nanomaterial decoration on to their surface would enable access to tunable 2D nanomaterial properties to improve cancer PTT. Here, we first time report a robust route for deposition of tantalum (TaO2) on to chitosan (CS) coated molybdenum sulphite (MoS2) nanosheet surface via electrostatic interaction, which assists to improve cancer PTT efficiency. Detailed studies prove that prepared TaO2-CS-MoS2 nanomaterial shows lack of toxicity, photostability and PCE was calculated from 26 °C to 47.2 °C under the 808 nm irradiation/5 min. Therefore, the TaO2 deposition particularly interest to promote the photostability, biocompatibility and PCE of bare MoS2 nanosheets. Therefore, the possible mechanism is highly expected to improve biological features in cancer PTT. Keywords: MoS2 nanosheet, Tantalum oxide, Chitosan, Cancer photothermal therapyhttp://www.sciencedirect.com/science/article/pii/S1878535219301388
collection DOAJ
language English
format Article
sources DOAJ
author Srinivasan Rajasekar
Esther Monisha Martin
Santhi Kuppusamy
Cittrarasu Vetrivel
spellingShingle Srinivasan Rajasekar
Esther Monisha Martin
Santhi Kuppusamy
Cittrarasu Vetrivel
Chitosan coated molybdenum sulphide nanosheet incorporated with tantalum oxide nanomaterials for improving cancer photothermal therapy
Arabian Journal of Chemistry
author_facet Srinivasan Rajasekar
Esther Monisha Martin
Santhi Kuppusamy
Cittrarasu Vetrivel
author_sort Srinivasan Rajasekar
title Chitosan coated molybdenum sulphide nanosheet incorporated with tantalum oxide nanomaterials for improving cancer photothermal therapy
title_short Chitosan coated molybdenum sulphide nanosheet incorporated with tantalum oxide nanomaterials for improving cancer photothermal therapy
title_full Chitosan coated molybdenum sulphide nanosheet incorporated with tantalum oxide nanomaterials for improving cancer photothermal therapy
title_fullStr Chitosan coated molybdenum sulphide nanosheet incorporated with tantalum oxide nanomaterials for improving cancer photothermal therapy
title_full_unstemmed Chitosan coated molybdenum sulphide nanosheet incorporated with tantalum oxide nanomaterials for improving cancer photothermal therapy
title_sort chitosan coated molybdenum sulphide nanosheet incorporated with tantalum oxide nanomaterials for improving cancer photothermal therapy
publisher Elsevier
series Arabian Journal of Chemistry
issn 1878-5352
publishDate 2020-03-01
description In recent years, two-dimensional nanomaterials (2D) prominent for site specific photothermal treatment (PTT), which are one of the most interesting strategy due to their maximizing cancer cell killing efficiency without the normal cells. Several robust methods are established for 2D material synthesis and improving the photothermal conversion efficiency (PCE), biocompatibility, and photostability in cancer PTT. Such preferred mechanism like nanomaterial decoration on to their surface would enable access to tunable 2D nanomaterial properties to improve cancer PTT. Here, we first time report a robust route for deposition of tantalum (TaO2) on to chitosan (CS) coated molybdenum sulphite (MoS2) nanosheet surface via electrostatic interaction, which assists to improve cancer PTT efficiency. Detailed studies prove that prepared TaO2-CS-MoS2 nanomaterial shows lack of toxicity, photostability and PCE was calculated from 26 °C to 47.2 °C under the 808 nm irradiation/5 min. Therefore, the TaO2 deposition particularly interest to promote the photostability, biocompatibility and PCE of bare MoS2 nanosheets. Therefore, the possible mechanism is highly expected to improve biological features in cancer PTT. Keywords: MoS2 nanosheet, Tantalum oxide, Chitosan, Cancer photothermal therapy
url http://www.sciencedirect.com/science/article/pii/S1878535219301388
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