| Summary: | In recent years, two-dimensional nanomaterials (2D) prominent for site specific photothermal treatment (PTT), which are one of the most interesting strategy due to their maximizing cancer cell killing efficiency without the normal cells. Several robust methods are established for 2D material synthesis and improving the photothermal conversion efficiency (PCE), biocompatibility, and photostability in cancer PTT. Such preferred mechanism like nanomaterial decoration on to their surface would enable access to tunable 2D nanomaterial properties to improve cancer PTT. Here, we first time report a robust route for deposition of tantalum (TaO2) on to chitosan (CS) coated molybdenum sulphite (MoS2) nanosheet surface via electrostatic interaction, which assists to improve cancer PTT efficiency. Detailed studies prove that prepared TaO2-CS-MoS2 nanomaterial shows lack of toxicity, photostability and PCE was calculated from 26 °C to 47.2 °C under the 808 nm irradiation/5 min. Therefore, the TaO2 deposition particularly interest to promote the photostability, biocompatibility and PCE of bare MoS2 nanosheets. Therefore, the possible mechanism is highly expected to improve biological features in cancer PTT. Keywords: MoS2 nanosheet, Tantalum oxide, Chitosan, Cancer photothermal therapy
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