Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells

• Main Authors: Zhuo Zhang, Shu-Zhen Yang, You-Fu Qi, Yong Yin
• Format: Article
• Language: English
• Published: Termedia Publishing House 2021-10-01
• Series: Folia Neuropathologica
• Subjects: glioma; proliferation; invasion; mir-21-5p; tet1.
• Online Access: https://www.termedia.pl/Identification-of-miR-21-5p-TET1-negative-regulation-pair-in-the-aggressiveness-of-glioma-cells,20,45022,1,1.html
• ISSN: 1641-4640; 1509-572X

Increasing evidence highlights that microRNAs (miRNAs) drive glioma initiation and development. Nevertheless, the underlying role of miR-21-5p in glioma is elusive. Hence, we evaluated the underlying role of miR-21-5p in glioma progression. Microarray data analysis provided data indicating that the miR-21-5p level was elevated in glioma. Silenced miR-21-5p suppressed glioma cell growth and invasion. Additionally, our results disclosed that ten-eleven translocation 1 (TET1) was directly targeted by miR-21-5p. Furthermore, antagomir-21-5p restrained glioma cell growth in a xenograft tumour model. In rescue experiments, knockdown of TET1 neutralized miR-21-5p silence-mediated inhibitory function on glioma cell aggressiveness. Taken together, miR-21-5p exerted its carcinogenic effect in glioma cell growth and invasin by targeting TET1.