HIF1A-AS2 induces osimertinib resistance in lung adenocarcinoma patients by regulating the miR-146b-5p/IL-6/STAT3 axis

HIF1A-AS2 induces osimertinib resistance in lung adenocarcinoma patients by regulating the miR-146b-5p/IL-6/STAT3 axis

Although epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) show efficacy in lung adenocarcinoma (LUAD) patients, TKI resistance inevitably develops, limiting long-term results. Thus, there is an urgent need to address drug resistance in LUAD. Long non-coding RNA (lncRNA) HIF1A-AS2 c...

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Bibliographic Details
Main Authors: Jiahui Si, Yuanyuan Ma, Chao Lv, Yang Hong, Hongyu Tan, Yue Yang
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
HIF1A-AS2
miR-146b-5p
IL-6
osimertinib resistance
lung cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121002328

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