Synthesis, Characterization And Antitumor Activity Of Copper(II) Complexes, [CuL2] [HL1-3=N,N-Diethyl-N'-(R-Benzoyl)Thiourea (R=H, o-Cl and p-NO2)]

Synthesis, Characterization And Antitumor Activity Of Copper(II) Complexes, [CuL2] [HL1-3=N,N-Diethyl-N'-(R-Benzoyl)Thiourea (R=H, o-Cl and p-NO2)]

The copper (II) complexes (CuL2) were prepared by reaction of Cu(CH3COO)2 with the corresponding derivatives of acylthioureas in a Cu:HL molar ratio of 1:2. Acylthiourea ligands, N,N-diethyl-N'-(R-benzoyl) thiourea (HL1-3) [R=H, o-Cl and p-NO2] were synthesized in high yield (78-83%) and charac...

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Bibliographic Details
Main Authors: Wilfredo Hernández, Evgenia Spodine, Lothar Beyer, Uwe Schröder, Rainer Richter, Jorge Ferreira, Mario Pavani
Format: Article
Language:English
Published: Hindawi Limited 2005-01-01
Series:Bioinorganic Chemistry and Applications
Subjects:
Copper(II) complexes; Acylthiourea; Antitumor / cytotoxic activity; Cell growth; Cellular DNA.
Online Access:http://dx.doi.org/10.1155/BCA.2005.299

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