Protective effects of medicinal plant breviscapine on postcerebral hemorrhage in rats

• Main Author: Zupeng Chen, Cheng Wang, Yajun Liu, Xiaolong Liang, Chao Yang, Xin Zhang, Xu Li
• Format: Article
• Language: English
• Published: IMR (Innovative Medical Research) Press Limited 2020-03-01
• Series: Journal of Integrative Neuroscience
• Subjects: |breviscapin|cerebral hemorrhage|periostin|nf-κb|inflammatory|rat
• Online Access: https://jin.imrpress.com/fileup/1757-448X/PDF/1585708664635-613991955.pdf

Medicinal plant breviscapine is shown to exhibit a protective role in tissue damage after cerebral hemorrhage. The effects of breviscapine on neurological deficit score, brain tissue water content, brain pathological tissue changes, blood-brain barrier bidirectional regulation, and inflammatory factors after cerebral hemorrhage in rats were observed. Western blot and real-time quantitative polymerase chain reaction were performed to explore how Periostin and nuclear factor kappa-B pathway-related factors protein expression contribute to the protective effects of breviscapine on brain injury. Breviscapine inhalation could reduce neurological deficit scores and brain tissue water content. Hematoxylin-eosin staining showed that breviscapine could improve the pathological changes of brain tissue and alleviate brain damage. Breviscapine reduced the abnormal increase of Evans blue content caused by a cerebral hemorrhage, and could significantly inhibit the levels of inflammatory factors interleukin-6 and tumor necrosis factor-α. Also, breviscapine significantly inhibited the expressions of Periostin and nuclear factor kappa-B pathway-related factors after cerebral hemorrhage, and alleviate brain damage by down-regulating Periostin expression and inhibiting nuclear factor kappa-β signaling pathway.