Immune modulation resulting from MR-guided high intensity focused ultrasound in a model of murine breast cancer
Abstract High intensity focused ultrasound (HIFU) rapidly and non-invasively destroys tumor tissue. Here, we sought to assess the immunomodulatory effects of MR-guided HIFU and its combination with the innate immune agonist CpG and checkpoint inhibitor anti-PD-1. Mice with multi-focal breast cancer...
Main Authors: | Brett Z. Fite, James Wang, Aris J. Kare, Asaf Ilovitsh, Michael Chavez, Tali Ilovitsh, Nisi Zhang, Weiyu Chen, Elise Robinson, Hua Zhang, Azadeh Kheirolomoom, Matthew T. Silvestrini, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah M. Tam, Ryan R. Davis, Clifford G. Tepper, Alexander D. Borowsky, Katherine W. Ferrara |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-01-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-80135-1 |
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