Cascade enzymes within self-assembled hybrid nanogel mimicked neutrophil lysosomes for singlet oxygen elevated cancer therapy

Enzymatic reactions caused by neutrophils can cause the elevation of reactive oxygen species (ROS) in tumour tissue, Here, the authors, inspired by the neutrophils, design and test a synthetic cascade reaction which turns ROS into singlet oxygen and demonstrate the application of the designed nanopa...

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Main Authors:	Qing Wu, Zhigang He, Xia Wang, Qi Zhang, Qingcong Wei, Sunqiang Ma, Cheng Ma, Jiyu Li, Qigang Wang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-08234-2

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spelling	doaj-3b01bc0ceb0948a497595aa20af974c02021-05-11T11:31:52ZengNature Publishing GroupNature Communications2041-17232019-01-0110111410.1038/s41467-018-08234-2Cascade enzymes within self-assembled hybrid nanogel mimicked neutrophil lysosomes for singlet oxygen elevated cancer therapyQing Wu0Zhigang He1Xia Wang2Qi Zhang3Qingcong Wei4Sunqiang Ma5Cheng Ma6Jiyu Li7Qigang Wang8School of Chemical Science and Engineering, Shanghai Tenth People’s Hospital & Putuo District People’s Hospital, Tongji UniversitySchool of Chemical Science and Engineering, Shanghai Tenth People’s Hospital & Putuo District People’s Hospital, Tongji UniversitySchool of Chemical Science and Engineering, Shanghai Tenth People’s Hospital & Putuo District People’s Hospital, Tongji UniversitySchool of Chemical Science and Engineering, Shanghai Tenth People’s Hospital & Putuo District People’s Hospital, Tongji UniversitySchool of Chemical Science and Engineering, Shanghai Tenth People’s Hospital & Putuo District People’s Hospital, Tongji UniversitySchool of Chemical Science and Engineering, Shanghai Tenth People’s Hospital & Putuo District People’s Hospital, Tongji UniversitySchool of Chemical Science and Engineering, Shanghai Tenth People’s Hospital & Putuo District People’s Hospital, Tongji UniversitySchool of Chemical Science and Engineering, Shanghai Tenth People’s Hospital & Putuo District People’s Hospital, Tongji UniversitySchool of Chemical Science and Engineering, Shanghai Tenth People’s Hospital & Putuo District People’s Hospital, Tongji UniversityEnzymatic reactions caused by neutrophils can cause the elevation of reactive oxygen species (ROS) in tumour tissue, Here, the authors, inspired by the neutrophils, design and test a synthetic cascade reaction which turns ROS into singlet oxygen and demonstrate the application of the designed nanoparticlehttps://doi.org/10.1038/s41467-018-08234-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Qing Wu Zhigang He Xia Wang Qi Zhang Qingcong Wei Sunqiang Ma Cheng Ma Jiyu Li Qigang Wang
spellingShingle	Qing Wu Zhigang He Xia Wang Qi Zhang Qingcong Wei Sunqiang Ma Cheng Ma Jiyu Li Qigang Wang Cascade enzymes within self-assembled hybrid nanogel mimicked neutrophil lysosomes for singlet oxygen elevated cancer therapy Nature Communications
author_facet	Qing Wu Zhigang He Xia Wang Qi Zhang Qingcong Wei Sunqiang Ma Cheng Ma Jiyu Li Qigang Wang
author_sort	Qing Wu
title	Cascade enzymes within self-assembled hybrid nanogel mimicked neutrophil lysosomes for singlet oxygen elevated cancer therapy
title_short	Cascade enzymes within self-assembled hybrid nanogel mimicked neutrophil lysosomes for singlet oxygen elevated cancer therapy
title_full	Cascade enzymes within self-assembled hybrid nanogel mimicked neutrophil lysosomes for singlet oxygen elevated cancer therapy
title_fullStr	Cascade enzymes within self-assembled hybrid nanogel mimicked neutrophil lysosomes for singlet oxygen elevated cancer therapy
title_full_unstemmed	Cascade enzymes within self-assembled hybrid nanogel mimicked neutrophil lysosomes for singlet oxygen elevated cancer therapy
title_sort	cascade enzymes within self-assembled hybrid nanogel mimicked neutrophil lysosomes for singlet oxygen elevated cancer therapy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-01-01
description	Enzymatic reactions caused by neutrophils can cause the elevation of reactive oxygen species (ROS) in tumour tissue, Here, the authors, inspired by the neutrophils, design and test a synthetic cascade reaction which turns ROS into singlet oxygen and demonstrate the application of the designed nanoparticle
url	https://doi.org/10.1038/s41467-018-08234-2
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Cascade enzymes within self-assembled hybrid nanogel mimicked neutrophil lysosomes for singlet oxygen elevated cancer therapy

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