C-fos upregulates P-glycoprotein, contributing to the development of multidrug resistance in HEp-2 laryngeal cancer cells with VCR-induced resistance

C-fos upregulates P-glycoprotein, contributing to the development of multidrug resistance in HEp-2 laryngeal cancer cells with VCR-induced resistance

Abstract Background Laryngeal cancer tends to have a very poor prognosis due to the unsatisfactory efficacy of chemotherapy for this cancer. Multidrug resistance (MDR) is the main cause of chemotherapy failure. The proto-oncogene c-fos has been shown to be involved in the development of MDR in sever...

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Bibliographic Details
Main Authors: Guodong Li, Xiaoling Hu, Lu Sun, Xin Li, Jianfeng Li, Tongli Li, Xiaohui Zhang
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Cellular & Molecular Biology Letters
Subjects:
C-fos
P-glycoprotein
Multidrug resistance
Laryngeal carcinoma
Online Access:http://link.springer.com/article/10.1186/s11658-017-0067-8

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http://link.springer.com/article/10.1186/s11658-017-0067-8

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