Association between TGFβ1 polymorphisms and chronic hepatitis B infection in an Iranian population
Abstract INTRODUCTION: Transforming growth factor-beta 1 (TGFβ1) is a potent suppressive cytokine that contributes to chronic hepatitis B (CHB) infection. Disparities in TGFβ1 production among individuals have been attributed to TGFβ1 genetic polymorphisms. We examined whether three putative polymo...
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doaj-3aff3d23ffe74733974baf28af38c95f2020-11-24T23:41:22ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-984950330130810.1590/0037-8682-0266-2016S0037-86822017002300301Association between TGFβ1 polymorphisms and chronic hepatitis B infection in an Iranian populationEbrahim EskandariMalihe MetanatElham PahlevaniTooba Nakhzari-KhodakheirAbstract INTRODUCTION: Transforming growth factor-beta 1 (TGFβ1) is a potent suppressive cytokine that contributes to chronic hepatitis B (CHB) infection. Disparities in TGFβ1 production among individuals have been attributed to TGFβ1 genetic polymorphisms. We examined whether three putative polymorphisms in TGFβ1[-509 C/T (rs1800469), +869 C/T (rs1800470), and +11929 C/T (rs1800472)]are associated with CHB infection in a South-Eastern Iranian population. METHODS: In total, 341 subjects were recruited, including 178 patients with CHB and 163 healthy individuals as controls. Genotyping of the three TGFβ1 SNPs was performed by tetra amplification refractory mutation system-PCR. RESULTS: TheTGFβ1 +869 TT vs.CC genotype in codominant (OR=0.445, p=0.012) and TT vs. TC+CC in the recessive (OR=0.439, p=0.003) model as well as the variant allele T vs. C(OR=0.714, p=0.038) were associated with lower CHB infection risk. However, the +11929 C/T polymorphism was associated with increased CHB risk, and the CT vs. CC genotype (OR=2.77, P=0.001) and T variant allele (OR=2.53, P=0.002) were risk factors for CHB. Furthermore, TTT (+869/-509/+11929) and CCC haplotypes were risk and protective factors for CHB, respectively. We found no significant association between viral DNA load and TGFβ1 genotype or hepatic enzyme levels (p >0.05). CONCLUSIONS: Results indicated that the TGFβ1+869TT genotype and T allele were protective factors, whereas the +11929 CT genotype and T allele were risk factors for CHB infection.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017002300301&lng=en&tlng=enChronic hepatitis B infectionGene polymorphismTGFβ1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ebrahim Eskandari Malihe Metanat Elham Pahlevani Tooba Nakhzari-Khodakheir |
spellingShingle |
Ebrahim Eskandari Malihe Metanat Elham Pahlevani Tooba Nakhzari-Khodakheir Association between TGFβ1 polymorphisms and chronic hepatitis B infection in an Iranian population Revista da Sociedade Brasileira de Medicina Tropical Chronic hepatitis B infection Gene polymorphism TGFβ1 |
author_facet |
Ebrahim Eskandari Malihe Metanat Elham Pahlevani Tooba Nakhzari-Khodakheir |
author_sort |
Ebrahim Eskandari |
title |
Association between TGFβ1 polymorphisms and chronic hepatitis B infection in an Iranian population |
title_short |
Association between TGFβ1 polymorphisms and chronic hepatitis B infection in an Iranian population |
title_full |
Association between TGFβ1 polymorphisms and chronic hepatitis B infection in an Iranian population |
title_fullStr |
Association between TGFβ1 polymorphisms and chronic hepatitis B infection in an Iranian population |
title_full_unstemmed |
Association between TGFβ1 polymorphisms and chronic hepatitis B infection in an Iranian population |
title_sort |
association between tgfβ1 polymorphisms and chronic hepatitis b infection in an iranian population |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
series |
Revista da Sociedade Brasileira de Medicina Tropical |
issn |
1678-9849 |
description |
Abstract INTRODUCTION: Transforming growth factor-beta 1 (TGFβ1) is a potent suppressive cytokine that contributes to chronic hepatitis B (CHB) infection. Disparities in TGFβ1 production among individuals have been attributed to TGFβ1 genetic polymorphisms. We examined whether three putative polymorphisms in TGFβ1[-509 C/T (rs1800469), +869 C/T (rs1800470), and +11929 C/T (rs1800472)]are associated with CHB infection in a South-Eastern Iranian population. METHODS: In total, 341 subjects were recruited, including 178 patients with CHB and 163 healthy individuals as controls. Genotyping of the three TGFβ1 SNPs was performed by tetra amplification refractory mutation system-PCR. RESULTS: TheTGFβ1 +869 TT vs.CC genotype in codominant (OR=0.445, p=0.012) and TT vs. TC+CC in the recessive (OR=0.439, p=0.003) model as well as the variant allele T vs. C(OR=0.714, p=0.038) were associated with lower CHB infection risk. However, the +11929 C/T polymorphism was associated with increased CHB risk, and the CT vs. CC genotype (OR=2.77, P=0.001) and T variant allele (OR=2.53, P=0.002) were risk factors for CHB. Furthermore, TTT (+869/-509/+11929) and CCC haplotypes were risk and protective factors for CHB, respectively. We found no significant association between viral DNA load and TGFβ1 genotype or hepatic enzyme levels (p >0.05). CONCLUSIONS: Results indicated that the TGFβ1+869TT genotype and T allele were protective factors, whereas the +11929 CT genotype and T allele were risk factors for CHB infection. |
topic |
Chronic hepatitis B infection Gene polymorphism TGFβ1 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017002300301&lng=en&tlng=en |
work_keys_str_mv |
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