Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss

Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss

Regulators of mTORC1, such as Tsc1, are involved in neurodevelopmental disorders associated with autism, intellectual disabilities and epilepsy. The authors identify a role of mTORC1 signaling in the regulation and maintenance of cortical parvalbumin cell connectivity and social behaviour.

Bibliographic Details
Main Authors: Clara A. Amegandjin, Mayukh Choudhury, Vidya Jadhav, Josianne Nunes Carriço, Ariane Quintal, Martin Berryer, Marina Snapyan, Bidisha Chattopadhyaya, Armen Saghatelyan, Graziella Di Cristo
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23939-7

Internet

https://doi.org/10.1038/s41467-021-23939-7

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