In vitro study of sirolimus release from nonwoven PLLA matrices

In vitro study of sirolimus release from nonwoven PLLA matrices

Sirolimus incorporated nonwoven polymer matrices were fabricated via electrospinning. Release kinetics considering different fiber diameters and layer thicknesses were investigated. In vitro drug release profiles were evaluated by measuring the drug concentration in an established drug release mediu...

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Bibliographic Details
Main Authors: Illner Sabine, Kohse Stefanie, Michaelis Claudia, Reske Thomas, Grabow Niels, Schmitz Klaus-Peter, Eickner Thomas
Format: Article
Language:English
Published: De Gruyter 2018-09-01
Series:Current Directions in Biomedical Engineering
Subjects:
drug release
fibrous material
nonwoven
film layer
surface modification
hydrophilization
Online Access:https://doi.org/10.1515/cdbme-2018-0142

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