14-3-3 Proteins in Glutamatergic Synapses

14-3-3 Proteins in Glutamatergic Synapses

The 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and...

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Main Authors: Jiajing Zhang, Yi Zhou
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2018/8407609
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spelling doaj-3ae9fec508ad4397be4c5fa40652e8832020-11-24T21:40:28ZengHindawi LimitedNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/8407609840760914-3-3 Proteins in Glutamatergic SynapsesJiajing Zhang0Yi Zhou1Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USADepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USAThe 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins at glutamatergic synapses. A key challenge for the future is to delineate the 14-3-3-dependent molecular pathways involved in regulating synaptic functions.http://dx.doi.org/10.1155/2018/8407609
collection DOAJ
language English
format Article
sources DOAJ
author Jiajing Zhang
Yi Zhou
spellingShingle Jiajing Zhang
Yi Zhou
14-3-3 Proteins in Glutamatergic Synapses
Neural Plasticity
author_facet Jiajing Zhang
Yi Zhou
author_sort Jiajing Zhang
title 14-3-3 Proteins in Glutamatergic Synapses
title_short 14-3-3 Proteins in Glutamatergic Synapses
title_full 14-3-3 Proteins in Glutamatergic Synapses
title_fullStr 14-3-3 Proteins in Glutamatergic Synapses
title_full_unstemmed 14-3-3 Proteins in Glutamatergic Synapses
title_sort 14-3-3 proteins in glutamatergic synapses
publisher Hindawi Limited
series Neural Plasticity
issn 2090-5904
1687-5443
publishDate 2018-01-01
description The 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins at glutamatergic synapses. A key challenge for the future is to delineate the 14-3-3-dependent molecular pathways involved in regulating synaptic functions.
url http://dx.doi.org/10.1155/2018/8407609
work_keys_str_mv AT jiajingzhang 1433proteinsinglutamatergicsynapses
AT yizhou 1433proteinsinglutamatergicsynapses
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