Poly(lactic-co-glycolic acid)-based composite bone-substitute materials

Poly(lactic-co-glycolic acid)-based composite bone-substitute materials

Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics. Recently, poly(lactic-co-glycolic acid) (PLGA)-based artificial bone-substitute materials are attracting incr...

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Main Authors: Duoyi Zhao, Tongtong Zhu, Jie Li, Liguo Cui, Zhiyu Zhang, Xiuli Zhuang, Jianxun Ding
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-02-01
Series:Bioactive Materials
Subjects:
Poly(lactic-co-glycolic acid)
Composite organic−inorganic biomaterial
Bone-substitute material
Bone tissue engineering
Bone regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X20301729
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spelling doaj-3add4350c1504065af6cf07932011f8b2021-04-02T18:03:40ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2021-02-0162346360Poly(lactic-co-glycolic acid)-based composite bone-substitute materialsDuoyi Zhao0Tongtong Zhu1Jie Li2Liguo Cui3Zhiyu Zhang4Xiuli Zhuang5Jianxun Ding6Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China; Department of Orthopedics, The Fourth Affiliated Hospital of China Medical University, 4 Chongshandong Road, Shenyang, 110032, PR ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China; Department of Orthopedics, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130033, PR ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China; Jilin Biomedical Polymers Engineering Laboratory, 5625 Renmin Street, Changchun, 130022, PR China; Corresponding author. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China.Department of Orthopedics, The Fourth Affiliated Hospital of China Medical University, 4 Chongshandong Road, Shenyang, 110032, PR ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China; Jilin Biomedical Polymers Engineering Laboratory, 5625 Renmin Street, Changchun, 130022, PR ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China; Jilin Biomedical Polymers Engineering Laboratory, 5625 Renmin Street, Changchun, 130022, PR China; Corresponding author. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China.Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics. Recently, poly(lactic-co-glycolic acid) (PLGA)-based artificial bone-substitute materials are attracting increasing attention as the benefit of their suitable biocompatibility, degradability, mechanical properties, and capabilities to promote bone regeneration. In this article, we comprehensively review the artificial bone-substitute materials made from PLGA or the composites of PLGA and other organic and inorganic substances, elaborate on their applications for bone regeneration with or without bioactive factors, and prospect the challenges and opportunities in clinical bone regeneration.http://www.sciencedirect.com/science/article/pii/S2452199X20301729Poly(lactic-co-glycolic acid)Composite organic−inorganic biomaterialBone-substitute materialBone tissue engineeringBone regeneration
collection DOAJ
language English
format Article
sources DOAJ
author Duoyi Zhao
Tongtong Zhu
Jie Li
Liguo Cui
Zhiyu Zhang
Xiuli Zhuang
Jianxun Ding
spellingShingle Duoyi Zhao
Tongtong Zhu
Jie Li
Liguo Cui
Zhiyu Zhang
Xiuli Zhuang
Jianxun Ding
Poly(lactic-co-glycolic acid)-based composite bone-substitute materials
Bioactive Materials
Poly(lactic-co-glycolic acid)
Composite organic−inorganic biomaterial
Bone-substitute material
Bone tissue engineering
Bone regeneration
author_facet Duoyi Zhao
Tongtong Zhu
Jie Li
Liguo Cui
Zhiyu Zhang
Xiuli Zhuang
Jianxun Ding
author_sort Duoyi Zhao
title Poly(lactic-co-glycolic acid)-based composite bone-substitute materials
title_short Poly(lactic-co-glycolic acid)-based composite bone-substitute materials
title_full Poly(lactic-co-glycolic acid)-based composite bone-substitute materials
title_fullStr Poly(lactic-co-glycolic acid)-based composite bone-substitute materials
title_full_unstemmed Poly(lactic-co-glycolic acid)-based composite bone-substitute materials
title_sort poly(lactic-co-glycolic acid)-based composite bone-substitute materials
publisher KeAi Communications Co., Ltd.
series Bioactive Materials
issn 2452-199X
publishDate 2021-02-01
description Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics. Recently, poly(lactic-co-glycolic acid) (PLGA)-based artificial bone-substitute materials are attracting increasing attention as the benefit of their suitable biocompatibility, degradability, mechanical properties, and capabilities to promote bone regeneration. In this article, we comprehensively review the artificial bone-substitute materials made from PLGA or the composites of PLGA and other organic and inorganic substances, elaborate on their applications for bone regeneration with or without bioactive factors, and prospect the challenges and opportunities in clinical bone regeneration.
topic Poly(lactic-co-glycolic acid)
Composite organic−inorganic biomaterial
Bone-substitute material
Bone tissue engineering
Bone regeneration
url http://www.sciencedirect.com/science/article/pii/S2452199X20301729
work_keys_str_mv AT duoyizhao polylacticcoglycolicacidbasedcompositebonesubstitutematerials
AT tongtongzhu polylacticcoglycolicacidbasedcompositebonesubstitutematerials
AT jieli polylacticcoglycolicacidbasedcompositebonesubstitutematerials
AT liguocui polylacticcoglycolicacidbasedcompositebonesubstitutematerials
AT zhiyuzhang polylacticcoglycolicacidbasedcompositebonesubstitutematerials
AT xiulizhuang polylacticcoglycolicacidbasedcompositebonesubstitutematerials
AT jianxunding polylacticcoglycolicacidbasedcompositebonesubstitutematerials
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