Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion

Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion

Abstract The effective treatment of bipolar disorder (BD) represents a significant unmet medical need. Although lithium remains a mainstay of treatment for BD, limited knowledge regarding how it modulates affective behavior has proven an obstacle to discovering more effective mood stabilizers with f...

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Bibliographic Details
Main Authors: Wen-Ning Zhao, Brian T. D. Tobe, Namrata D. Udeshi, Lucius L. Xuan, Cameron D. Pernia, Daniel P. Zolg, Amanda J. Roberts, Deepak Mani, Sarah R. Blumenthal, Iren Kurtser, Debasis Patnaik, Irina Gaisina, Joshua Bishop, Steven D. Sheridan, Jasmin Lalonde, Steven A. Carr, Evan Y. Snyder, Stephen J. Haggarty
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-020-0753-6

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