Satisfaction survey with DNA cards method to collect genetic samples for pharmacogenetics studies

• Main Authors: Mas Herrero Sergio, Cucala Mercedes, Vidal-Taboada Jose M, Lafuente Amalia, Cobos Albert
• Format: Article
• Language: English
• Published: BMC 2006-05-01
• Series: BMC Medical Genetics
• Online Access: http://www.biomedcentral.com/1471-2350/7/45

<p>Abstract</p> <p>Background</p> <p>Pharmacogenetic studies are essential in understanding the interindividual variability of drug responses. DNA sample collection for genotyping is a critical step in genetic studies. A method using dried blood samples from finger-puncture, collected on DNA-cards, has been described as an alternative to the usual venepuncture technique. The purpose of this study is to evaluate the implementation of the DNA cards method in a multicentre clinical trial, and to assess the degree of investigators' satisfaction and the acceptance of the patients perceived by the investigators.</p> <p>Methods</p> <p>Blood samples were collected on DNA-cards. The quality and quantity of DNA recovered were analyzed. Investigators were questioned regarding their general interest, previous experience, safety issues, preferences and perceived patient satisfaction.</p> <p>Results</p> <p>151 patients' blood samples were collected. Genotyping of <it>GST </it>polymorphisms was achieved in all samples (100%). 28 investigators completed the survey. Investigators perceived patient satisfaction as very good (60.7%) or good (39.3%), without reluctance to finger puncture. Investigators preferred this method, which was considered safer and better than the usual methods. All investigators would recommend using it in future genetic studies.</p> <p>Conclusion</p> <p>Within the clinical trial setting, the DNA-cards method was very well accepted by investigators and patients (in perception of investigators), and was preferred to conventional methods due to its ease of use and safety.</p>