Antioxidants protect keratinocytes against M. ulcerans mycolactone cytotoxicity.

Antioxidants protect keratinocytes against M. ulcerans mycolactone cytotoxicity.

BACKGROUND: Mycobacterium ulcerans is the causative agent of necrotizing skin ulcerations in distinctive geographical areas. M. ulcerans produces a macrolide toxin, mycolactone, which has been identified as an important virulence factor in ulcer formation. Mycolactone is cytotoxic to fibroblasts and...

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Bibliographic Details
Main Authors: Alvar Grönberg, Louise Zettergren, Kerstin Bergh, Mona Ståhle, Johan Heilborn, Kristian Angeby, Pamela L Small, Hannah Akuffo, Sven Britton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2973957?pdf=render

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