Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays
Abstract Comparing seroprevalence and antibody kinetics in three different commercially available assays for SARS-CoV-2. Serostatus of COVID-19 patients was analyzed 5 months and 10 months after their infection, using three different assays: Diasorin LIAISON, Euroimmun, Abbott Diagnostics ARCHITECT....
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-07-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-94453-5 |
| id |
doaj-3ad06cb755d9481f99002db848a9c614 |
|---|---|
| record_format |
Article |
| spelling |
doaj-3ad06cb755d9481f99002db848a9c6142021-07-25T11:27:24ZengNature Publishing GroupScientific Reports2045-23222021-07-011111610.1038/s41598-021-94453-5Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assaysElisabeth Kahre0Lukas Galow1Manja Unrath2Luise Haag3Judith Blankenburg4Alexander H. Dalpke5Christian Lück6Reinhard Berner7Jakob P. Armann8Department of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität DresdenDepartment of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität DresdenDepartment of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität DresdenDepartment of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität DresdenDepartment of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität DresdenMedical Faculty Carl Gustav Carus, Institute for Medical Microbiology and Virology, Technische Universität DresdenMedical Faculty Carl Gustav Carus, Institute for Medical Microbiology and Virology, Technische Universität DresdenDepartment of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität DresdenDepartment of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität DresdenAbstract Comparing seroprevalence and antibody kinetics in three different commercially available assays for SARS-CoV-2. Serostatus of COVID-19 patients was analyzed 5 months and 10 months after their infection, using three different assays: Diasorin LIAISON, Euroimmun, Abbott Diagnostics ARCHITECT. Seropositivity at baseline differed significantly depending on the assay (Diasorin 81%, Euroimmun 83%, Abbott 59%). At follow-up antibody levels detected in the Diasorin assay were stable, while there was a significant loss in seropositivity in the Euroimmun and Abbott assays. There are significant differences in SARS-CoV-2 antibody kinetics based on the specific assay used.https://doi.org/10.1038/s41598-021-94453-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Elisabeth Kahre Lukas Galow Manja Unrath Luise Haag Judith Blankenburg Alexander H. Dalpke Christian Lück Reinhard Berner Jakob P. Armann |
| spellingShingle |
Elisabeth Kahre Lukas Galow Manja Unrath Luise Haag Judith Blankenburg Alexander H. Dalpke Christian Lück Reinhard Berner Jakob P. Armann Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays Scientific Reports |
| author_facet |
Elisabeth Kahre Lukas Galow Manja Unrath Luise Haag Judith Blankenburg Alexander H. Dalpke Christian Lück Reinhard Berner Jakob P. Armann |
| author_sort |
Elisabeth Kahre |
| title |
Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays |
| title_short |
Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays |
| title_full |
Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays |
| title_fullStr |
Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays |
| title_full_unstemmed |
Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays |
| title_sort |
kinetics and seroprevalence of sars-cov-2 antibodies: a comparison of 3 different assays |
| publisher |
Nature Publishing Group |
| series |
Scientific Reports |
| issn |
2045-2322 |
| publishDate |
2021-07-01 |
| description |
Abstract Comparing seroprevalence and antibody kinetics in three different commercially available assays for SARS-CoV-2. Serostatus of COVID-19 patients was analyzed 5 months and 10 months after their infection, using three different assays: Diasorin LIAISON, Euroimmun, Abbott Diagnostics ARCHITECT. Seropositivity at baseline differed significantly depending on the assay (Diasorin 81%, Euroimmun 83%, Abbott 59%). At follow-up antibody levels detected in the Diasorin assay were stable, while there was a significant loss in seropositivity in the Euroimmun and Abbott assays. There are significant differences in SARS-CoV-2 antibody kinetics based on the specific assay used. |
| url |
https://doi.org/10.1038/s41598-021-94453-5 |
| work_keys_str_mv |
AT elisabethkahre kineticsandseroprevalenceofsarscov2antibodiesacomparisonof3differentassays AT lukasgalow kineticsandseroprevalenceofsarscov2antibodiesacomparisonof3differentassays AT manjaunrath kineticsandseroprevalenceofsarscov2antibodiesacomparisonof3differentassays AT luisehaag kineticsandseroprevalenceofsarscov2antibodiesacomparisonof3differentassays AT judithblankenburg kineticsandseroprevalenceofsarscov2antibodiesacomparisonof3differentassays AT alexanderhdalpke kineticsandseroprevalenceofsarscov2antibodiesacomparisonof3differentassays AT christianluck kineticsandseroprevalenceofsarscov2antibodiesacomparisonof3differentassays AT reinhardberner kineticsandseroprevalenceofsarscov2antibodiesacomparisonof3differentassays AT jakobparmann kineticsandseroprevalenceofsarscov2antibodiesacomparisonof3differentassays |
| _version_ |
1721283167393939456 |