Evaluation of Health-Related Quality of Life among Tuberculosis Patients in Two Cities in Yemen.

BACKGROUND:The health-related quality of life (HRQoL) of Tuberculosis (TB) patients is important because it directly influences the outcome of TB patients in several aspects. The current study aims to evaluate and to find the factors influencing the HRQoL of TB patients in two major TB-prevalent cit...

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Main Authors: Ammar Ali Saleh Jaber, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Nafees Ahmad, Mohamed Saif Anaam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4892669?pdf=render
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spelling doaj-3acd91b2ee6f4e7a8a4f87cc484d27282020-11-24T21:14:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01116e015625810.1371/journal.pone.0156258Evaluation of Health-Related Quality of Life among Tuberculosis Patients in Two Cities in Yemen.Ammar Ali Saleh JaberAmer Hayat KhanSyed Azhar Syed SulaimanNafees AhmadMohamed Saif AnaamBACKGROUND:The health-related quality of life (HRQoL) of Tuberculosis (TB) patients is important because it directly influences the outcome of TB patients in several aspects. The current study aims to evaluate and to find the factors influencing the HRQoL of TB patients in two major TB-prevalent cities (Taiz and Alhodidah) in Yemen. METHODS:A prospective study was conducted, and all TB patients meeting the HRQoL criteria were asked to complete the HRQoL SF-36 survey. The records of TB patients were examined for disease confirmation, and a follow-up was consequently performed for patients during treatment between March 2013 and February 2014 in Taiz and Alhodidah Cities. HRQol scores were calculated by using QM scoring software version 4.5, in which the physical component score (PCS) and mental component score (MCS) were obtained. The scores obtained between 47-53 normal based score (NBS) were considered equivalent to the US normal score. Low scores indicate the poor health situation of TB patients. RESULTS:A total of 243 TB patients enrolled in the study at the beginning of the treatment. A total of 235 and 197 TB patients completed the questionnaire at the end of the intensive phase (I.P.) and continuation phase (C.P.), respectively. The final dropout rate was 16.2%. The mean PCS and MCS scores at the beginning of treatment were low, thus showing the poor health situation of TB patients. The mean PCS scores at the beginning of treatment, end of I.P., and end of treatment were (36.1), (44.9), and (48), respectively. Moreover, the mean MCS score at the beginning of treatment, end of I.P., and end of treatment were (35.1), (42.2), and (44.3), respectively. The result shows that significant increases are observed at the end of I.P. for PCS and MCS because of the treatment and slight changes at the end of C.P. Despite this finding, the MCS score remains below the normal range (47), thus indicating a significant risk of depression among TB patients. Furthermore, general linear repeated measure ANOVA was performed for selected variables, to examine the changes of PCS and MCS over time. It was found that Alhodiah city, chewing khat habit, stigmatization, and duration of treatment more than six months were greatly associated with low mean MCS score of TB patient, indicating great risk of depression which may result in poor treatment outcome. CONCLUSION:TB patients in Yemen were found to have poor QoL, with a significant likelihood of depression. Highly risk depression was found among TB patients in Alhodiah city, khat chewers, stigmatization and having a duration of treatment more than 6 months. Therefore, additional efforts should be made to improve their QoL because it may affect the final clinical outcome of patients.http://europepmc.org/articles/PMC4892669?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Ammar Ali Saleh Jaber
Amer Hayat Khan
Syed Azhar Syed Sulaiman
Nafees Ahmad
Mohamed Saif Anaam
spellingShingle Ammar Ali Saleh Jaber
Amer Hayat Khan
Syed Azhar Syed Sulaiman
Nafees Ahmad
Mohamed Saif Anaam
Evaluation of Health-Related Quality of Life among Tuberculosis Patients in Two Cities in Yemen.
PLoS ONE
author_facet Ammar Ali Saleh Jaber
Amer Hayat Khan
Syed Azhar Syed Sulaiman
Nafees Ahmad
Mohamed Saif Anaam
author_sort Ammar Ali Saleh Jaber
title Evaluation of Health-Related Quality of Life among Tuberculosis Patients in Two Cities in Yemen.
title_short Evaluation of Health-Related Quality of Life among Tuberculosis Patients in Two Cities in Yemen.
title_full Evaluation of Health-Related Quality of Life among Tuberculosis Patients in Two Cities in Yemen.
title_fullStr Evaluation of Health-Related Quality of Life among Tuberculosis Patients in Two Cities in Yemen.
title_full_unstemmed Evaluation of Health-Related Quality of Life among Tuberculosis Patients in Two Cities in Yemen.
title_sort evaluation of health-related quality of life among tuberculosis patients in two cities in yemen.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2016-01-01
description BACKGROUND:The health-related quality of life (HRQoL) of Tuberculosis (TB) patients is important because it directly influences the outcome of TB patients in several aspects. The current study aims to evaluate and to find the factors influencing the HRQoL of TB patients in two major TB-prevalent cities (Taiz and Alhodidah) in Yemen. METHODS:A prospective study was conducted, and all TB patients meeting the HRQoL criteria were asked to complete the HRQoL SF-36 survey. The records of TB patients were examined for disease confirmation, and a follow-up was consequently performed for patients during treatment between March 2013 and February 2014 in Taiz and Alhodidah Cities. HRQol scores were calculated by using QM scoring software version 4.5, in which the physical component score (PCS) and mental component score (MCS) were obtained. The scores obtained between 47-53 normal based score (NBS) were considered equivalent to the US normal score. Low scores indicate the poor health situation of TB patients. RESULTS:A total of 243 TB patients enrolled in the study at the beginning of the treatment. A total of 235 and 197 TB patients completed the questionnaire at the end of the intensive phase (I.P.) and continuation phase (C.P.), respectively. The final dropout rate was 16.2%. The mean PCS and MCS scores at the beginning of treatment were low, thus showing the poor health situation of TB patients. The mean PCS scores at the beginning of treatment, end of I.P., and end of treatment were (36.1), (44.9), and (48), respectively. Moreover, the mean MCS score at the beginning of treatment, end of I.P., and end of treatment were (35.1), (42.2), and (44.3), respectively. The result shows that significant increases are observed at the end of I.P. for PCS and MCS because of the treatment and slight changes at the end of C.P. Despite this finding, the MCS score remains below the normal range (47), thus indicating a significant risk of depression among TB patients. Furthermore, general linear repeated measure ANOVA was performed for selected variables, to examine the changes of PCS and MCS over time. It was found that Alhodiah city, chewing khat habit, stigmatization, and duration of treatment more than six months were greatly associated with low mean MCS score of TB patient, indicating great risk of depression which may result in poor treatment outcome. CONCLUSION:TB patients in Yemen were found to have poor QoL, with a significant likelihood of depression. Highly risk depression was found among TB patients in Alhodiah city, khat chewers, stigmatization and having a duration of treatment more than 6 months. Therefore, additional efforts should be made to improve their QoL because it may affect the final clinical outcome of patients.
url http://europepmc.org/articles/PMC4892669?pdf=render
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